Tissue stem cells


Skin stem cells

The skin protects our bodies from daily wear and tear, harmful microbes, and other assaults from the external environment. Tissue stem cells work to maintain the skin’s function, and restore it after injury.

Cartoon of the skin and its appendages. A hair follicle is illustrated on the left and an eccrine sweat gland on the right.

Healing skin after a shallow wound. Hair follicle stem cells of the bulge are traced with a green fluorescent reporter. Basal cells are immunostained with α6 in white, suprabasal cells with K10 in red, and nuclei with DAPI in blue.


Regeneration and repair

Stem cells are sentinels of their environment, rapidly adapting their activities to urgent physiological needs. This plasticity allows them to regenerate and repair tissue through the processes of migration, proliferation, metabolism and/or changes in cellular identity .


Epigenetic memory

Stem cells have the ability to remember the diverse experiences that they encounter throughout their lifetimes. Acute stimuli can thus have long-term repercussions on health and disease.

Tuft of growing hair after grafting of hair stem cells into the back of a nude mouse. Skin stem cells inherit this ability if they were former hair stem cells.

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